Phosphorus, Sulfur, and Silicon and the Related Elements · Apr 30, 2026
4-amino-3-(phenylselanyl)benzenesulfonamide: a new therapeutic approach to mitigating aging-induced hepatic and renal oxidative damage in hamsters
By Wille APB, Martins CC, da Motta KP et al.
Aging is a multifactorial process characterized by increased production of reactive species (RS), which contribute to the development of pathologies, particularly liver and kidney diseases. 4-amino-3-(phenylselanyl)benzenesulfonamide (4-APSB) has emerged as a potential therapeutic candidate due to its antioxidant properties. This study evaluated the antioxidant effects of 4-APSB in the liver and kidney of aged hamsters. Male Golden Syrian hamster (Mesocricetus auratus) aged 2 and 20 months were assigned to three groups: Young, Old, and Old + 4-APSB. Animals received 4-APSB (1 mg/kg) or canola oil for 8 days, and liver, kidney and plasma were collected on day 12 for biochemical analysis. Protein carbonyl content (PCs), thiobarbituric acid reactive species (TBARS), RS levels, and the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), renal Na+/K+-ATPase, and non-protein thiol groups (NPSH) were measured in the liver and kidney. Aging induced oxidative imbalance, demonstrated by increased protein and lipid damage and alterations in antioxidant enzyme activities. Treatment with 4-APSB induced partial, tissue-specific antioxidant effects. Hepatic responses were broader, with improvements in oxidative damage, whereas renal effects were limited to redox modulation without consistent functional changes. These findings highlight tissue-specific sensitivity and warrant further investigation into the mechanisms of 4-APSB in age-related conditions.