AAIC 2025 Abstract
Discovery of an ApoE4‐Targeted Small‐Molecule SirT1 Enhancer for the Treatment of Alzheimer’s Disease
Experiments in animalsInterventions
Abstract
Background: Alzheimer’s disease (AD) is characterized by amyloid plaques and tau tangles, with apolipoprotein E4 (ApoE4) recognized as a strong genetic risk factor for sporadic AD. ApoE4 has been shown to repress the expression of Sirtuin 1 (SirT1), a key neuroprotective protein, contributing to disease progression.
