Frontiers in Neuroscience

Association of healthy sleep patterns with incident cervical disc disorders: a prospective study

Figure 1. Flowchart for the participants who were included in the analysis.
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Figure 1. Flowchart for the participants who were included in the analysis.Flowchart for the participants who were included in the analysis.Li et al.
Cohort study of 399,862 peoplePopulations
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Abstract

BACKGROUND: There is limited evidence regarding the relationship between multidimensional sleep behaviors and incident cervical disc disorders. This study examined whether a composite healthy sleep pattern was associated with the subsequent risk of cervical disc disorders. METHODS: This prospective cohort study used data from the UK Biobank. Participants with baseline cervical disc disorders or missing data were excluded, leaving 399,862 participants for analysis. A composite healthy sleep score was derived from five sleep characteristics: sleep chronotype, sleep duration, insomnia, snoring, and daytime sleepiness. The primary outcome was incident cervical disc disorders, identified using ICD-10 codes (M50). Cox proportional hazards models were fitted with adjustment for demographic, lifestyle, and socioeconomic covariates. RESULTS: During follow-up, 2,735 incident cases were documented. Each 1-point increase in the healthy sleep score was associated with an 18% lower risk (HR = 0.82; 95% CI: 0.79-0.85). Participants with a score of 5 had a lower risk than those with a score of 0-1 (HR = 0.43; 95% CI: 0.35-0.52). The inverse association was stronger among participants with higher socioeconomic deprivation (P for interaction = 0.018). CONCLUSION: In this cohort analysis, baseline adherence to healthy sleep behaviors was associated with a significantly lower risk of cervical disc disorders, suggesting that promoting healthy sleep may be a viable strategy for primary prevention.

From the paper

Participants

The final effective sample size for statistical analysis comprised 399,862 participants (see Figure 1 for details).

Methods, 2.1 Study design

Follow-up

Over a mean follow-up of 15.83 years (SD 2.67), 2,735 incident cervical disc disorder events were recorded.

Results, 3.2 Association between healthy sleep score and incident cervical disc disorders

Result

In fully adjusted Model 2, participants with a healthy sleep score of 5 had a substantially lower risk than those with a score of 0–1 (HR, 0.43; 95% CI 0.35–0.52; P trend < 0.001).

Results, 3.2 Association between healthy sleep score and incident cervical disc disorders

Limitation

Sleep patterns were self-reported at baseline, which may introduce measurement error.

4 Discussion

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