Communications Medicine · Sep 3, 2026

Applying a systemic approach that extends beyond the brain to Alzheimer's disease pathogenesis

By Barnaghi P, Fogel A, Walsh C et al.

Traditional dementia research often isolates single aspects, biomarkers or symptoms, overlooking complex interactions shaping disease risk and progression. Lysosomal and mitochondrial dysfunction, reflecting systemic processes, may explain links between Alzheimer’s and metabolic, inflammatory, cardiovascular, ageing, genetic, environmental, and endocrine factors.

doi.org/10.1038/s43856-026-01831-zOpen accessPubMed 42693207Mechanisms