Bioengineering · May 31, 2026

Targeting Dental Pulp Stem Cell Senescence: A Potential Strategy for Improving Regenerative Endodontic Procedures

By Christoffersen J, Bjørndal L, Dabelsteen S

The effects of aging on dental pulp stem cells (DPSCs) have been extensively investigated in recent years. Senescent DPSCs may negatively affect pulpal regeneration in the aged tooth and be a driver of chronic inflammation. In the near future, targeting key inducers of cellular senescence may therefore become central to the development of new strategies to enhance the regenerative capacities of DPSCs. The aim of this perspective article is to provide an overview of the molecular mechanisms driving cellular senescence in DPSCs. Furthermore, potential clinical applications of targeting DPSC senescence in regenerative endodontics are discussed, including strategies to preserve exposed pulp, promote pulp-like tissue through revascularization or revitalization, and achieve complete pulp regeneration.

doi.org/10.3390/bioengineering13060654 Open access PubMed 42351899 Mechanisms