An aminoacyl-tRNA synthetase governs dsRNA-mediated trade-off between longevity and innate immunity

In this issue of Molecular Cell, Sohn et al.¹ explore how endogenous dsRNAs influence organismal aging and identify an unexpected function of the aminoacyl-tRNA synthetase FARS-1/FARSA in regulating mitochondrial dsRNA homeostasis to balance longevity and innate immunity.