Journal of Alzheimer's Disease · Jun 4, 2026
Plasma p-tau217 and p-tau181 in middle-aged adults with mild cognitive impairment: The role of multimorbidity in an age-matched brief report
By Bożek A, Dobosz M, Miśkiewicz M et al.
Mild cognitive impairment (MCI) is an early stage of Alzheimer's disease-related neurodegeneration and may occur in midlife. The objective of the study was to assess associations between plasma p-tau217, p-tau181, cognition, and multimorbidity. We studied 236 MCI patients and 210 controls. Cognition was assessed using the Mini-Mental State Examination and Montreal Cognitive Assessment. Multimorbidity was defined as ≥2 chronic conditions, and comorbidity as coexisting diseases. MCI was associated with lower cognition, higher p-tau levels, and greater multimorbidity. Plasma p-tau217 correlated inversely with cognition. Plasma p-tau reflects early neurodegeneration, with multimorbidity contributing to cognitive decline.