Frontiers in Bioengineering and Biotechnology · Mar 4, 2026

Notch signaling pathway and heart development, congenital heart disease, and myocardial regeneration

By Liu Y, Wang X, Tao X et al.

This review summarizes the critical role of the Notch signaling pathway in cardiac development, congenital heart disease, and myocardial regeneration. The Notch signaling pathway exerts a profound impact on cardiac health and disease progression by finely regulating the fate determination of cardiac progenitor cells, cardiac morphogenesis, and the proliferation and apoptosis of cardiomyocytes. The article also explores the research progress of the Notch signaling pathway as a potential therapeutic target and looks forward to future research directions.

doi.org/10.3389/fbioe.2025.1731605 Open access PubMed 41859765 Mechanisms