The Nigerian Postgraduate Medical Journal · Mar 2, 2026

Correlation of Pulse Pressure Index and High-sensitivity C-reactive Protein as Predictors of Diastolic Dysfunction in Essential Hypertension - A Prospective Observational Study at a Tertiary Care Centre in Chengalpattu

By Rani TS, Nalabothula RT, Kumarasamy S et al.

BACKGROUND: Pulse pressure index (PPI) and high-sensitivity C-reactive protein (hs-CRP) are potential markers for vascular compliance and inflammation, respectively, and may predict diastolic dysfunction in hypertensive individuals. AIMS: This study aimed to evaluate the association of PPI and hs-CRP with diastolic dysfunction in newly diagnosed essential hypertensive patients. MATERIALS AND METHODS: This prospective observational study included 82 patients aged >40 years with newly diagnosed hypertension. Baseline PPI and hs-CRP levels were measured, and two-dimensional echocardiography was performed to assess and grade DD. Patients received standard antihypertensive therapy, and follow-ups were conducted at 3 and 6 months to reassess parameters. RESULTS: At baseline, 74.4% of patients had diastolic dysfunction, predominantly Grade 1 and 2. hs-CRP showed a strong positive association with diastolic dysfunction (β = 0.885, P = 0.025), while PPI had a moderate correlation (β = 0.475, P = 0.035). Antihypertensive therapy significantly improved diastolic function over 6 months (P = 0.032), though PPI did not show a significant change (P = 0.435). CONCLUSION: hs-CRP is a strong indicator of inflammation-driven diastolic dysfunction, while PPI serves as a surrogate for vascular stiffness. Early identification using these markers can enhance clinical assessment and guide timely intervention in hypertensive patients.

doi.org/10.4103/npmj.npmj_403_25 Open access PubMed 41766267 Biomarkers