Kidney International Reports · Dec 23, 2025

Visceral Adipose Tissue Alters Podometrics and Renal Compensation After Uninephrectomy

By Paschen C, Koeller MC, Hennenberg J et al.

INTRODUCTION: Obesity is an established risk factor for chronic kidney disease (CKD). However, excess visceral adipose tissue (VAT) termed visceral obesity (VO) can occur in individuals with normal body mass index (BMI) or overweight. VO is associated with impaired kidney function but its effect on kidney morphology remains unclear. This study aimed to examine the association of VO with glomerular ultrastructure, podocyte morphometry (podometrics), and the kidneys' ability for compensation after uninephrectomy in normal BMI and overweight individuals. METHODS: VAT was retrospectively quantified in computed tomography (CT) of 52 patients (BMI < 30 kg/m²) who underwent nephrectomy for nonmetastatic renal tumor without previous chemotherapy or immunotherapy. VO was defined as VAT area ≥ 100 cm². Histological sections from nontumorous kidney regions were examined using deep learning-supported glomerular morphometry and podometrics (podocyte count, density, and nuclear volume). Renal compensation in the first year after nephrectomy (change in estimated glomerular filtration rate [ΔeGFR]) was assessed using linear regression. RESULTS: Of the 52 subjects with normal BMI or overweight, 35 were diagnosed with VO and exhibited a larger glomerular volume (2.6 ± 0.7 vs. 2.0 ± 0.5 ×10⁶ μm³; P = 0.004), lower podocyte density (194 ± 50 vs. 243 ± 59 per 10⁶ μm³; P = 0.003), and podocyte nuclear hypertrophy (226 ± 27 vs. 195 ± 22 μm³; P < 0.001). VO was associated with impaired eGFR compensation after uninephrectomy (ΔeGFR: -24 ± 15 vs. -12 ± 12 ml/min per 1.73 m², P = 0.03). Structural changes, including glomerular enlargement (P = 0.005), podocyte density (P = 0.01), and nuclear hypertrophy (P = 0.003), were significantly associated with reduced ΔeGFR. CONCLUSION: VO was associated with glomerular and podocyte changes, and impaired kidney function compensation after nephrectomy in normal BMI and overweight individuals. These data suggest that VAT quantification could guide individual decision making in subjects planned for nephrectomy.

doi.org/10.1016/j.ekir.2025.103739 Open access PubMed 41727777 Mechanisms