Phenomics · Feb 21, 2025

Protocol for Retinal Imaging and Extraction of Imaging-Derived Phenotypes from the Chinese Human Phenome Project

By Lan L, Xu B, Yan Z et al.

UNLABELLED: Retinal imaging is pivotal in the evaluation of ocular and systemic health, presenting significant promise for extensive population studies. However, the lack of standardized and automated techniques for extracting Imaging-Derived Phenotypes (IDPs) from retinal images is a major impediment. To counteract this challenge, the Chinese Human Phenome Project (CHPP) has developed a comprehensive protocol that includes Quality Control (QC), preprocessing, and automated or semi-automated extraction of IDPs from fundus photography and Optical Coherence Tomography (OCT) images. This protocol incorporates Artificial Intelligence (AI)-based methods to achieve accurate and efficient IDP extraction, facilitating standardized analysis of large-scale populations. We hope that this Standard Operating Procedure (SOP) guideline will impart valuable insights for ophthalmology-related disciplines and provides support for future research endeavors utilizing retinal imaging data. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s43657-023-00155-5.

doi.org/10.1007/s43657-023-00155-5Open accessPubMed 41659738AI & data