Gastroenterology Clinics of North America · Nov 12, 2025

Biomarkers for the Diagnosis of Cirrhosis and Cirrhosis-Related Complications

By Hunold T, Govalan R, Parikh N

Cirrhosis is an increasingly prevalent condition, with significant associated morbidity and mortality due to the development of several complications, including portal hypertension and hepatocellular carcinoma (HCC). Early detection of significant liver fibrosis can lead to interventions to forestall complications and early detection of hepatic decompensation or liver cancer. Several noninvasive blood and imaging-based biomarkers exist for the detection of liver fibrosis, stratification of patients with cirrhosis for the risk of portal hypertensive complications, and for the early detection of HCC. We aim to summarize the data on promising biomarkers for the detection and risk stratification of patients with cirrhosis.

doi.org/10.1016/j.gtc.2025.10.006Open accessPubMed 41581950Biomarkers