Physiological Measurement · Jan 16, 2026

Ophthalmology foundation models for clinically significant age macular degeneration detection

By Cohen BA, Fhima J, Meisel M et al.

Objective. Self-supervised learning (SSL) has enabled vision transformers (ViTs) to learn robust representations from large-scale natural image datasets, enhancing their generalization across domains. In retinal imaging, foundation models pretrained on either natural or ophthalmic data have shown promise, but the benefits of in-domain pretraining remain uncertain.Approach. To investigate this, we benchmark six SSL-pretrained ViTs on seven digital fundus image (DFI) datasets totaling 70 000 expert-annotated images for the task of moderate-to-late age-related macular degeneration (AMD) identification.Main results. Our results show that DINOv2, pretrained on natural images, shows similar performance than domain-specific models. These findings highlight the value of foundation models in improving AMD identification, and challenge the assumption that in-domain pretraining is necessary.Significance. We present our model AMDNet, which performs state-of-the-art out-of-domain AUROCs on six public datasets. Furthermore, we release BRAMD, an open-access dataset (n = 587) of DFIs with AMD labels from Brazil. Project page:www.aimlab-technion.com/lirot-ai.

doi.org/10.1088/1361-6579/ae3936Open accessPubMed 41539007Biomarkers