Physics in Medicine and Biology · Jan 15, 2026

Coronary artery segmentation in non-contrast cardiac CT using anatomy-informed contrastive learning and synthetic data

By Hao J, He X, Durak G et al.

Objective.Non-contrast cardiac computed tomography (NCCT) offers a low-dose, cost-effective alternative to coronary CT angiography (CCTA) for large-scale coronary artery disease screening. However, automatic segmentation on NCCT is severely hindered by poor vessel visibility and a scarcity of annotated datasets. This study aims to overcome these limitations by developing a method for accurate coronary artery segmentation (CAS) from NCCT images without requiring manual annotations.Approach.We propose synthetic-data-driven CAS(SynCAS), a deep learning framework trained entirely on synthetic data. First, we developed a comprehensive generation pipeline to create a diverse, large-scale synthetic NCCT dataset with perfect ground truth, modeling the physics of NCCT imaging. Second, to address the low contrast-to-noise ratio, we introduced an anatomy-informed contrastive learning strategy. Unlike traditional methods, this strategy utilizes voxel-level pseudo-negative samples guided by anatomical priors, enabling the model to effectively distinguish coronary arteries from visually similar background structures and reduce false positives.Main results.The proposed method was evaluated on both a public NCCT dataset and an in-house clinical dataset. Experimental results demonstrate that SynCAS consistently outperforms state-of-the-art unsupervised and domain-adaptation approaches. The model exhibits strong generalization capabilities across different datasets despite being trained without real-world annotations.Significance.SynCAS provides a robust solution for analyzing coronary arteries in non-contrast imaging, potentially facilitating retrospective analysis and large-scale population screening for cardiovascular risk without the radiation dose and contrast agent risks associated with CCTA. Code and model weights will be available at:https://github.com/Advanced-AI-in-Medicine-and-Physics-Lab/SynCAS.git.

doi.org/10.1088/1361-6560/ae387c Open access PubMed 41534216 Biomarkers