Clinical Interventions in Aging · Jan 9, 2026

Correlation of Cerebral Oxygen Saturation Change with Perioperative Complications in Elderly Patients Who Underwent Laparoscopic Partial Hepatectomy

By Li T, Guo R, Xu G

BACKGROUND: Laparoscopic partial hepatectomy is a crucial treatment for primary liver cancer but is associated with risks such as bleeding and organ hypoperfusion due to controlled low central venous pressure (CLCVP). Regional cerebral oxygen saturation (rSO₂), measured using near-infrared spectroscopy (NIRS), serves as a reliable indicator of cerebral perfusion. This study aims to investigate the relationship between intraoperative rSO₂ changes, perioperative outcomes, and neurological complications. METHODS: This retrospective study analyzed 218 elderly patients undergoing laparoscopic partial hepatectomy, grouped based on intraoperative rSO₂ reductions of ≥10% and ≥20%. Perioperative complications were assessed. Serum neuron-specific enolase (NSE) levels were measured on postoperative day 3 via enzyme-linked immunosorbent assay. Hemodynamic parameters, including mean arterial pressure (MAP), were monitored intraoperatively. RESULTS: Among the 218 patients, significant rSO₂ reductions were linked to higher risks of neurological complications. Patients with ≥20% rSO₂ reductions had increased incidences of delirium (30.5% vs 13.0%, p = 0.002), and elevated serum NSE levels (p < 0.05). Declines in MAP during critical intraoperative periods were associated with rSO₂ reductions. Patients with marked rSO₂ drops also experienced prolonged hospital stays. CONCLUSION: Intraoperative rSO₂ reductions, especially >20%, are linked to adverse neurological outcomes and delayed recovery. Combined rSO₂ and NSE monitoring offers a robust strategy to optimize cerebral perfusion and improve outcomes.

doi.org/10.2147/cia.s548590 Open access PubMed 41531791 Biomarkers