Cureus · Nov 19, 2025

Evaluating Sarcopenia Prevalence in Cirrhotic Patients and Its Association With Child-Turcotte-Pugh and MELD (Model for End-Stage Liver Disease) Scores: A Cross-Sectional Study

By John II, Kamlesh Kumar MJ, Koppath Parammal F et al.

BACKGROUND: Sarcopenia, defined as progressive loss of skeletal muscle strength and function, is a frequent but underrecognized complication of liver cirrhosis. It has been associated with increased morbidity and mortality, yet its prevalence and correlation with prognostic scores remain incompletely studied in the Indian population. The study aimed to determine the prevalence of sarcopenia in cirrhotic patients using handgrip strength and to evaluate the correlation between sarcopenia and liver disease severity, Child-Turcotte-Pugh (CTP) score, and Model for End-Stage Liver Disease (MELD) score. METHODS: A cross-sectional study was conducted among 75 adult cirrhotic patients. Handgrip strength was measured using a handheld dynamometer, and sarcopenia was defined as <27 kg in men and <16 kg in women (European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria). Disease severity was assessed using CTP and MELD scores. Statistical analysis included Pearson correlation, with p<0.05 considered significant. RESULTS: The mean age of patients was 55.43 ± 11.54 years, with a male predominance of 54 (72%). Alcoholism was the leading etiology (n=45, 60%), followed by nonalcoholic steatohepatitis (NASH), hepatitis B virus (HBV), and hepatitis C virus (HCV). Mean MELD and CTP scores were 15.42 ± 6.32 and 8.42 ± 2.65, respectively, with most patients in CTP class B (60%). The overall mean handgrip strength was 26.69 ± 4.76 kg, higher in male patients than in female patients. The prevalence of sarcopenia was 42.7%. Handgrip strength declined across CTP classes (28.45 ± 5.65 kg in A, 26.87 ± 3.89 kg in B, and 21.65 ± 2.42 kg in C; p=0.001). Significant negative correlations were observed between handgrip strength and MELD (r = -0.412, p<0.001) as well as CTP (r = -0.358, p=0.01). CONCLUSION: Sarcopenia is highly prevalent in cirrhosis, particularly in patients with alcohol-related disease and advanced CTP class. Handgrip strength correlates strongly with MELD and CTP scores, making it a simple and effective prognostic tool in routine practice.

doi.org/10.7759/cureus.97292 Open access PubMed 41426776 Biomarkers