American Journal of Hypertension · Dec 16, 2025
Geriatric Nutritional Risk Index in Relation to Ambulatory Blood Pressure in Elderly Patients with Hypertension
By Wang D, Xu JZ, Kang YY et al.
BACKGROUND: Malnutrition may negatively influence cardiovascular outcomes. We investigated the association between geriatric nutritional risk index (GNRI) and ambulatory blood pressure in elderly patients with hypertension. METHODS: Our study included 235 elderly hypertensive patients with malnutrition (GNRI ≤98) and 391 patients with normal nutrition (GNRI > 98). All patients underwent ambulatory blood pressure monitoring and assessment of nutritional status including total protein, prealbumin, and serum albumin. RESULTS: Patients with malnutrition, compared with normal nutrition, were older, and had a significantly (P ≤ .05) higher serum creatinine, and lower body weight, estimated glomerular filtration rate, serum low density lipoprotein cholesterol, serum total protein, prealbumin, and albumin, body mass index and GNRI (P ≤ .01). After multivariable adjustment, malnourished patients had significantly higher 24-h, daytime and nighttime systolic blood pressure (P ≤ .001). Lower GNRI was independently associated with higher 24-h, daytime and nighttime systolic blood pressure after adjustment for confounding factors (P < .05). CONCLUSIONS: Elderly hypertensive patients with malnutrition had higher systolic blood pressure than those with normal nutrition. GNRI was associated with 24-h, daytime and nighttime systolic blood pressure.