Trends in Biochemical Sciences

Unlocking the protein code: how our organs age across a lifetime

CommentaryBiomarkers
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Abstract

A recent study by Ding et al. harnesses cutting-edge proteomics to explore protein changes linked to human aging over 50 years across 12 tissues and plasma. It uncovered asynchronous aging clocks in different organs, redefining aging as a coordinated, targetable network.

The paper

Beijing Proteome Research Center

Trends in Biochemical Sciences, 18 Nov 2025

doi.org/10.1016/j.tibs.2025.10.002PubMed 41253650