Aging and Disease · Oct 12, 2025

Metabolic-Inflammatory Syndrome: Decoding the Metabolic-Immune Axis for Precision Intervention

By Li S, Shi Y, You C

Metabolic-inflammatory syndrome represents a major global health challenge, closely linked to diabetes, cardiovascular disease, obesity, and non-alcoholic fatty liver disease. The core of these disorders involves remodeling of metabolic pathways under nutritional stress and the ensuing chronic inflammatory vicious cycle. This review systematically examines the mechanisms by which metabolic reprogramming drives metabolic-inflammatory syndrome, revealing the significant role of the gut microbiota in this process. Furthermore, it evaluates current metabolic-inflammatory syndrome early-warning systems and proposes innovative therapeutic strategies precisely targeting the metabolic-immune axis, establishing a foundation for enhancing early detection and clinical intervention.

doi.org/10.14336/ad.2025.1125 Open access PubMed 41135093 Mechanisms