Aging and Disease · Jul 18, 2025

Tissue Fibrosis Decoded via Cellular Senescence: Mechanisms, Treatments, and Emerging Technologies

By Cai W, Zhang H, Li Z et al.

Cellular senescence is one of the hallmarks of aging, and it is closely related to tissue fibrosis in various age-related diseases. By integrating multi-level and multi-dimensional data, emerging technologies can comprehensively analyze the complex mechanisms of aging and fibrosis diseases, discover new biomarkers and therapeutic targets, and promote the development of precision medicine. Most of the current reviews still focus on the molecular mechanisms of cellular senescence and fibrosis diseases, but lack a comprehensive summary of anti-aging drugs for the treatment of fibrosis-related diseases, and emerging technologies and integrated analysis of multi-omics data. This review discusses the latest evidence on the role of cellular senescence in tissue fibrosis, especially lungs, liver, and kidney fibrosis. In addition, we also introduce the application of anti-aging strategies in fibrotic diseases, especially drugs to eliminate senescent cells, and the latest application of emerging technologies in aging and fibrotic diseases.

doi.org/10.14336/ad.2025.0503Open accessPubMed 40768641Mechanisms