Frontiers in Nutrition · Jul 18, 2025

Association between the dietary index for gut microbiota and frailty: the mediating role of body mass index

By Lei J, Feng T, Tian T et al.

BACKGROUND: The Dietary Index for Gut Microbiota (DI-GM), a newly introduced metric, indicates gut microbiota diversity. However, its correlation with frailty remains unexplored. METHOD: A total of 25,320 individuals were included in the 2007-2020 National Health and Nutrition Examination Survey (NHANES). Dietary recall data were calculated by averaging intake values from two separate 24-h dietary recall interviews. Frailty was assessed using the 49-item frailty index. The relationship between DI-GM and the frailty phenomenon was examined by applying a weighted logistic regression model. A comprehensive sensitivity analysis was undertaken, incorporating restricted cubic splines for modeling non-linear effects, stratified subgroup analyses to explore effect modification, and multiple imputation techniques to address potential missing data concerns. RESULTS: Higher DI-GM scores and gut microbiota-beneficial dietary components were significantly associated with reduced prevalence of frailty (Frailty Index: OR = 0.987, 95% CI: 0.977-0.997, P = 0.014; Frailty: OR = 0.941, 95% CI: 0.902-0.980, P = 0.004). Restricted cubic spline analysis revealed a non-linear relationship between DI-GM and frailty. Body Mass Index (BMI) mediated this relationship, accounting for 17.57% of the association. CONCLUSION: We concluded that a higher DI-GM score is associated with a lower risk of frailty, partly via BMI mediation. Future research should validate these findings using longitudinal studies.

doi.org/10.3389/fnut.2025.1573199Open accessPubMed 40756558Populations