Trends in Cell Biology · Jan 21, 2025
Splice age: mTORC1-mediated RNA splicing in metabolism and ageing
By Lanuza-Gracia P, Juan-Mateu J, Valcárcel J
The target of rapamycin complex mTORC1 has key roles in cell growth and metabolism and its inhibition delays ageing. Recent work by Ogawa et al. in Caenorhabditis elegans argues that modulation of pre-mRNA splicing factors and alternative splicing are key mediators of mTORC1 signalling and can enhance longevity.