Trends in Biochemical Sciences · Oct 1, 2024

Bridging brain insulin resistance to Alzheimer's pathogenesis

By Chen W, Johansen VBI, Legido-Quigley C

Emerging evidence links type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), with brain insulin resistance (BIR) as a key factor. In a recent study, Lanzillotta et al. reveal that reduced biliverdin reductase-A (BVR-A) impairs glycogen synthase kinase 3β (GSK3β) phosphorylation, causing mitochondrial dysfunction and exacerbating brain insulin resistance in the progression of both T2DM and AD.

doi.org/10.1016/j.tibs.2024.09.004 Open access, accepted manuscript PubMed 39358050 Mechanisms