Trends in Immunology · Sep 25, 2024

Intracellular C1q - an unexpected player in neuronal proteostasis

By West EE, Kemper C

Extrahepatic, cell-autonomous, and/or intracellularly active complement components are increasingly recognized as key orchestrators of cell physiological processes. A recent study by Scott-Hewitt et al. demonstrates that microglia-derived C1q unexpectedly associates with the ribosomes of neurons in the aging murine brain, where it impacts protein translation and impairs the extinction of conditioned fear responses.

doi.org/10.1016/j.it.2024.09.006Open access, accepted manuscriptPubMed 39327206Mechanisms