Trends in Pharmacological Sciences · Jan 20, 2024

Revisiting sensitivity of senescent cells to BH3 mimetics

By Martin N, Huna A, Tsalikis A et al.

B cell leukemia/lymphoma 2 (BCL2) homology domain 3 (BH3) mimetics were reported to selectively kill senescent cells and improve age-related diseases. Defining why these cells show increased sensitivity to these molecules will help to identify new pharmacological compounds with senolytic activity. Here, we discuss how recent research findings provide new clues to understand this vulnerability.

doi.org/10.1016/j.tips.2024.01.002 Open access, accepted manuscript PubMed 38245492 Mechanisms