Immunity · Dec 12, 2023

A maelstrom of migrating monocytes drives neurodegeneration

By Coufal NG, Hermiston ML

Neurodegeneration is a devastating complication of Langerhans cell histiocytosis (LCH), but it is not clear how it develops. In this issue of Immunity, Wilk et al. demonstrate that circulating BRAFV600E⁺ myeloid cells damage the blood-brain barrier and infiltrate the brain. Dual inhibition of the MAPK and senescence pathways can block parenchymal injury, providing a potential therapeutic avenue for histiocytic neurodegeneration.

doi.org/10.1016/j.immuni.2023.11.014Open accessPubMed 38091948Mechanisms