Cancer Cell · Jun 1, 2023

Senescent macrophages: A new "old" player in lung cancer development

By Zhou L, Ruscetti M

Senescent cells accumulate following oncogene induction, but their role in transformation remains unclear. Prieto et al. and Haston et al. found that senescent cells in premalignant lung lesions are mainly macrophages that promote lung tumorigenesis, and removing them through senolytic approaches can prevent malignant progression.

doi.org/10.1016/j.ccell.2023.05.008Open accessPubMed 37267952Mechanisms