Gan to Kagaku Ryoho Cancer & Chemotherapy · Feb 2023
Clonal Hematopoiesis and Solid Cancer
By Sakata-Yanagimoto M, Makishima K, Suehara Y
In the hematopoietic system of healthy individuals, a phenomenon called clonal hematopoiesis, in which cells acquired somatic mutations are replaced with aging, has been discovered. The frequency of clonal hematopoiesis is higher in patients with solid tumors, than normal individuals. In addition, it is thought that infiltration of inflammatory cells with somatic mutations into cancer tissues may change the tumor microenvironment. Since clonal hematopoiesis is often found incidentally in gene panel testing of solid cancer tissues, it is of great significance to have an insight into clonal hematopoiesis in the medical care of solid cancer patients. In this paper, we describe the general concept of clonal hematopoiesis, the frequency of clonal hematopoiesis in patients with solid tumors, the characteristics of the clinical course in patients with clonal hematopoiesis, and microscopic observations of solid tumors in mouse models of clonal hematopoiesis.