Nature Aging · Aug 11, 2022
Landscape of somatic mutations in aging human heart muscle cells
By Walsh C, Choudhury S, Chen MH
Using single-cell whole-genome sequencing, we identified and characterized the landscape of somatic single-nucleotide variants (sSNVs) in single cardiomyocytes from individuals across the human lifespan. Aged cardiomyocytes were found to have a higher burden of sSNVs and show mutational signatures that suggest failed repair of oxidative DNA damage.