Frontiers in Aging · Sep 13, 2022

Minimum standards for evaluating machine-learned models of high-dimensional data

By Chen BH

The maturation of machine learning and technologies that generate high dimensional data have led to the growth in the number of predictive models, such as the "epigenetic clock". While powerful, machine learning algorithms run a high risk of overfitting, particularly when training data is limited, as is often the case with high-dimensional data ("large p, small n"). Making independent validation a requirement of "algorithmic biomarker" development would bring greater clarity to the field by more efficiently identifying prediction or classification models to prioritize for further validation and characterization. Reproducibility has been a mainstay in science, but only recently received attention in defining its various aspects and how to apply these principles to machine learning models. The goal of this paper is merely to serve as a call-to-arms for greater rigor and attention paid to newly developed models for prediction or classification.

doi.org/10.3389/fragi.2022.901841Open accessPubMed 36176975AI & data