Molecular Cell
Coping with starvation: Cysteine keeps mTORC1 suppressed to ensure survival
CommentaryMechanisms
Abstract
Jouandin et al. (2022) show that lysosomal-derived cysteine serves as a signal to promote the tricarboxylic acid (TCA) cycle and suppress TORC1 signaling for Drosophila to endure starvation periods.
The paper
Children's Medical Center
Molecular Cell, May 1, 2022, Open access
