Trends in Cancer · Feb 16, 2022

A tipping point in cancer epidemiology: embracing a life course exposomic framework

By Wright RJ, Hanson HA

The pathogenesis of multifactorial malignant diseases, with variable onset, severity, and natural history, reflects development-specific exposures and individual responses to these exposures influenced by underlying genetic predisposition. Embedded in life course theory, exposomics provides a framework to more fully elucidate how environmental factors alter cancer risk, disease course, and response to treatment across the lifespan.

doi.org/10.1016/j.trecan.2022.01.016Open access, accepted manuscriptPubMed 35181274Populations