Cell Metabolism · Jun 1, 2021

Brains and brawn: Stress-induced myokine abates nervous system aging

By Tsui CK, Dishart JG, Dillin A

Skeletal muscle secretes numerous systemic factors, termed myokines, which can regulate homeostasis of distal tissues. In this issue, Rai et al. (2021) identify and characterize a novel myokine, Amyrel, which is secreted under muscle proteasome stress and protects central nervous system health and function by enhancing protein quality control during aging.

doi.org/10.1016/j.cmet.2021.05.007Open accessPubMed 34077712Mechanisms