Exercise and Sport Sciences Reviews · May 1, 2021

A High-Fat Diet Aggravates the Age-Related Decline in Skeletal Muscle Structure and Function

By Degens H, Swaminathan A, Tallis J

The age-related decline in muscle function is aggravated by a high-fat diet (HFD)-induced increase in fat mass. The hypothesis is that an HFD leads to a faster accumulation of intramyocellular lipids (IMCL) and an earlier onset of muscle dysfunction in old than in young-adult individuals. The IMCL accumulation is attenuated in young-adult organisms by an elevated oxidative capacity. Methionine restriction enhances mitochondrial biogenesis and is promising to combat obesity across the ages.

doi.org/10.1249/jes.0000000000000261PubMed 33927161Mechanisms