World Journal of Surgical Oncology · Mar 16, 2021

Does cellular senescence play an important role in the prognosis of sarcomatoid carcinoma of the pancreas?

By Kimura T, Togawa T, Iida A et al.

AIM: Sarcomatoid carcinoma of the pancreas (SCP) is an extremely rare and aggressive disease with poor prognosis. We have already reported a rare case of SCP with long-term survival. In the present article, we investigate the underlying mechanisms of patient's long-term survival from the point of view of cellular senescence which was examined in three SCP cases, including our reported case, using immunohistochemical analysis. FINDINGS: The expressions of cellular senescence marker were observed in the sarcomatous component of the patient with long-term survival but not observed in the other patients with short- term survival. Thus, we can speculate that cellular senescence might play an important role in the reduction of the cell proliferative and metastatic activities of sarcomatous cells, leading to long-term patient survival.

doi.org/10.1186/s12957-021-02177-7 Open access PubMed 33726729 Mechanisms