Kidney International · Nov 2020

The transcriptomic signature of the aging podocyte

By Mukhi D, Susztak K

Aging is the strongest independent risk factor for chronic kidney disease. Glomerular epithelial cells are unable to proliferate and have limited ability to renew; therefore, podocytes must maintain a delicate intracellular homeostasis that enables them to function and adapt to stress endured during the human life span. Here, Wang et al. performed unbiased transcriptomic analysis of aging podocytes and identified important novel regulators.

doi.org/10.1016/j.kint.2020.08.004Open accessPubMed 33126968Mechanisms