Mechanisms of Ageing and Development · Jun 5, 2020

MicroRNAs in hematopoietic stem cell aging

By Luinenburg DG, de Haan G

The functional decline that is observed in HSCs upon aging is attributed mainly to cell intrinsic factors that regulate quiescence, self-renewal and differentiation. MicroRNAs (miRs) have an indispensable role in the regulation of HSCs and have been shown to also regulate processes related to tissue aging in specific cell types. Here we discuss the role of miRs in the regulation of HSC self-renewal and differentiation throughout life and its implications for future research.

doi.org/10.1016/j.mad.2020.111281 Open access PubMed 32512019 Mechanisms