Nature Neuroscience · May 18, 2020

Shared proteomic effects of cerebral atherosclerosis and Alzheimer's disease on the human brain

By Wingo AP, Fan W, Duong DM et al.

Cerebral atherosclerosis contributes to dementia via unclear processes. We performed proteomic sequencing of dorsolateral prefrontal cortex in 438 older individuals and found associations between cerebral atherosclerosis and reduced synaptic signaling and between RNA splicing and increased oligodendrocyte development and myelination. Consistently, single-cell RNA sequencing showed cerebral atherosclerosis associated with higher oligodendrocyte abundance. A subset of proteins and modules associated with cerebral atherosclerosis was also associated with Alzheimer's disease, suggesting shared mechanisms.

doi.org/10.1038/s41593-020-0635-5Open access, accepted manuscriptPubMed 32424284Mechanisms