Cell Metabolism · May 12, 2020

CD4⁺ T Cells at the Center of Inflammaging

By Kroemer G, Zitvogel L

Bharath et al., 2020 report that CD4⁺ T lymphocytes from aged individuals exhibit defective mitochondrial autophagy, resulting in altered redox metabolism and upregulation of TH17 cytokines, which in turn may contribute to aging-associated chronic inflammation or "inflammaging." Of note, the antiaging drug metformin reverses this autophagy defect and rejuvenates CD4⁺ T cell function.

doi.org/10.1016/j.cmet.2020.04.016Open accessPubMed 32402265Mechanisms