Nature Neuroscience · Sep 24, 2019

Common brain disorders are associated with heritable patterns of apparent aging of the brain

By Kaufmann T, van der Meer D, Doan NT et al.

Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.

doi.org/10.1038/s41593-019-0471-7 Open access, accepted manuscript PubMed 31551603 Biomarkers