Essays in Biochemistry · Jul 11, 2017

Systems modelling ageing: from single senescent cells to simple multi-cellular models

By Martinez Guimera A, Welsh C, Dalle Pezze P et al.

Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing. Modelling frameworks to allow integration of models and methods to enhance confidence in models are now well established. In this article, we discuss these issues and work through the process of building an integrated model for cellular senescence as a single cell and in a simple tissue context.

doi.org/10.1042/ebc20160087 Open access PubMed 28698310 Mechanisms