Molecular & Cellular Oncology · May 5, 2015

Influence of metabolic stress on translation of p53 isoforms

By Khan D, Chattopadhyay S, Das S

p53 and its isoforms are integral in modulating transcriptional gene expression programs and maintaining cellular homeostasis. We recently reported that glucose deprivation/caloric restriction induced translational control of p53 mRNA by scaffold/matrix attachment region binding-protein 1 (SMAR1), adding a cytoplasmic role of SMAR1 to its traditional nuclear role as a transcription factor.

doi.org/10.1080/23723556.2015.1039689 Open access PubMed 27308557 Mechanisms