Kidney International · Apr 12, 2016

In experimental chronic kidney disease or cancer, parathyroid hormone is a novel mediator of cachexia

By Wyatt CM, Mitch WE

Hyperparathyroidism plays a central role in the disordered bone mineral metabolism of chronic kidney disease, and has been associated with increased cardiovascular morbidity and mortality in that setting. A recent study suggests a novel role for parathyroid hormone and its receptor in muscle wasting and cachexia occurring in advanced chronic kidney disease.

doi.org/10.1016/j.kint.2016.03.003 Open access PubMed 27083271 Mechanisms