Genome Medicine · Mar 17, 2016

Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer

By Fox EJ, Salk JJ, Loeb LA

Signatures of mutagenesis provide a powerful tool for dissecting the role of somatic mutations in both normal and pathological processes. Significantly, cancer genomes are dominated by mutation signatures distinct from those that accumulate in normal tissues with age, with potentially important translational implications.

doi.org/10.1186/s13073-016-0286-zOpen accessPubMed 26987311Mechanisms