Uluslararası Sağlık Bilimlerinde Disiplinler Arası Etkileşim Dergisi · Oct 5, 2026
The Effects Of Chronıc Inflammatıon On Agıng And The Characterıstıcs Of The NLRP3 Inflammasome
By Başaran A
Ageing is a process known as ‘ageing by inflammation’, which is associated with the onset of chronic low-grade inflammation; it plays a role in many diseases, including neurodegenerative, cardiovascular and musculoskeletal disorders. Metabolic disorders, changes in the gut microbiota and the ageing of the immune system are among the factors that trigger inflammation. The NLRP3 inflammasome is associated with numerous age-related conditions, including cardiovascular, metabolic, neurodegenerative and other disorders. The literature suggests that NLRP3 ablation may prevent or alleviate certain diseases. Drug development studies have focused on inhibition achieved through compounds that reduce NLRP3 activity. This review summarises the regulation of the NLRP3 inflammasome, the underlying molecular mechanisms and the current state of knowledge; in particular, it emphasises the role of oxidative stress, caused by Reactive Oxygen Species (ROS), in the abnormal activation of the NLRP3 inflammasome and its components. Furthermore, attention is drawn to the complex relationship between age-related diseases, oxidative stress, antioxidants and inflammasome activation. In our study, a literature review was conducted using the following databases: PubMed, PubMed Central, Nature Portfolio, ScienceDirect, Europe PMC, Google Scholar, EBSCOhost, ResearchGate, Scopus, Web of Science (Science Citation Index Expanded, SCIE), EMBASE and Web of Science (WOS). The aim was to contribute to the current literature; our review does not form part of any thesis.