Mezhdunarodnyy Nauchno-issledovatelskiy Zhurnal · 2026
Vaginal dysbiosis in postmenopausal women: clinical significance and pathogenetic aspects
By Chiviev A.Ch., Emmanuilidi A.I., Kabolova M.T. et al.
This research presents a systematic review of current clinical and experimental data, analysing the associations between the structure of the vaginal microbiome and the severity of vaginal, sexual and urological symptoms, as well as the frequency of recurrent lower urinary tract infections. Particular attention is paid to the influence of comorbid conditions, including type 2 diabetes mellitus, on the worsening of dysbiotic changes. Separate attention is given to data on the systemic effects of vaginal dysbiosis, including the activation of pro-inflammatory signalling pathways and potential involvement in bone metabolism disorders. It is concluded that postmenopausal vaginal dysbiosis should be considered a significant biomarker and a promising therapeutic target in the comprehensive management of patients with genitourinary syndrome of menopause.