Zenodo · May 19, 2026
Experimental Evidence Supporting the Energy-Weighted Aging Derivative Theory
By yildirim B
The Energy-Weighted Aging Derivative Theory proposes that the rate of cellular aging (A) is proportional to the temporal change in ATP production (dATP/dt), modulated by environmental stress factors Φ(env). This hypothesis suggests that both excessive or deficient energy production can trigger senescence depending on how sharply ATP levels deviate from the optimal range. The goal of this document is to present a synthesis of experimental findings from various biological studies to evaluate the validity of this model. Originality and AI-use statement: This work is an original research output by Begüm Yıldırım. AI tools, if used, were limited to language refinement, grammar correction, formatting, translation assistance, and clarity improvement. The conceptual framework, research direction, interpretation, models, and conclusions belong to the author. External sources, datasets, or prior works are cited where applicable.