Journal Of Stem Cell Research · Oct 14, 2026
Increased IL-17A Levels Secreted by Adipose Derived Stem Cells Extracted from Geriatric Burn Patients
By Smith AA
Background: Burn injuries in the elderly population pose a difficult clinical dilemma.This population is commonly frail with impaired wound healing capabilities and dysregulation of cytokines.Adipose derived stem cells (ADSCs) play a major role in wound healing.The objective of this study was to determine if there was an alteration in the ADSC cytokine profile of geriatric burn patients.Methods: Adipose tissue was collected from burn patients at their initial excision.ADSCs were extracted, and the supernatant was collected.Cytokine analyses were performed with a multiplex assay.Patients were stratified into two groups: Non GeriBurn (<65 years old) and GeriBurn ( 65 years old).Mann-Whitney U test was used to compare the groups.Results: Thirteen patients were included (GeriBurn n=6).There was a significantly higher median concentration of interleukin-17 (IL-17) in the GeriBurn group (p=0.015).