Chinese Journal of Osteoporosis · Oct 23, 2026
Significance of matrix remodeling associated 7 expression in senile osteoporosis
By 孟淑艳
OBJECTIVE: To investigate the significance of matrix remodeling associated 7 (MXRA7) expression in older patients with osteoporosis (osteoporosis,OP). METHODS: A total of 102 older patients diagnosed with OP at our hospital from May 2023 to May 2024 were retrospectively included as the observation group, and 100 sex- and age-matched healthy individuals without OP were selected as the control group. Serum MXRA7 expression at admission was measured using real-time fluorescence quantitative PCR (qRT-PCR); serum levels of bone turnover markers (BTM), including osteocalcin (OC), procollagen type I N-terminal propeptide (PINP), and β-isomerized C-terminal telopeptide of type I collagen (β-CTX), were measured using electrochemiluminescence; and bone mineral density (BMD) at lumbar vertebrae 1～4, the femoral neck, and the total hip was measured using dual-energy X-ray absorptiometry. Patients in the observation group received comprehensive treatment according to guideline recommendations and were followed for at least 1 year, and fracture incidence was recorded. RESULTS: Before treatment, MXRA7 expression and BMD values in the observation group were significantly lower than those in the control group, whereas OC, PINP, and β-CTX levels were significantly higher than those in the control group (P<0.05). Pearson correlation analysis showed that MXRA7 expression was significantly negatively correlated with OC, PINP, and β-CTX levels and significantly positively correlated with BMD values (P<0.05). Following follow-up, 15 cases of fracture were recorded in the observation group, with an incidence of 14.7％. Serum MXRA7 expression both before and after treatment was significantly lower in the fracture subgroup than in the nonfracture subgroup (P<0.05). The receiver operating characteristic (ROC) curve showed that the area under the curve (AUC) for pretreatment MXRA7 expression in predicting posttreatment fractures was 0.854 (95％CI=0.801～0.899,P<0.001). CONCLUSIONS: Decreased MXRA7 expression may be closely associated with the occurrence and severity of senile OP and can serve as a novel marker for predicting fracture risk.