Yakut Medical Journal · Jun 21, 2026
Predictors of HBV-associated hepatocarcinoma: a scientific review
By Lobanova MA, Danilova NE, Слепцова СС et al.
The purpose of this work was to analyze and systematize the data of modern scientific literature on predictors of hepatocellular carcinoma (HCC) development in chronic hepatitis B. Studies show that the most significant risk factors for developing HCC are old age, male gender, genetic predisposition, presence of metabolic syndrome, liver fibrosis, smoking, alcohol consumption, exposure to hepatotropic toxins and environmental pollution. Of particular importance is the identification of mutant forms of hepatitis B virus, such as A1762T/G1764A, E64D, E77Q, and A80I/T which increase the risk of developing HCC. The development of universal and accessible diagnostic models that make it possible to identify patients at increased risk of developing HCC in a timely manner is a priority task for improving the quality of medical care and improving the effectiveness of combating this serious disease. Thus, the study confirms the importance of further studying the mechanisms of HCC development and introducing new approaches to the treatment and prevention of hepatitis B complications.